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Medicated Suppositories 3

Cannariginals Medicated Suppositories 10 pack

$80.00

Medicated Suppositories

The medicated suppositories come in a pack of 10 and each are 2 grams of emu oil with 5mg CBD and 2.5mg THC. They require refrigeration prior to use, and come in a plastic mold which is to be removed prior to use.  Emu oil is an excellent carrier for cannabinoids. Patients with hemorrhoids, Crohn’s disease, and more have had success with this medicine.

In stock

SKU: 2003 Categories: , Tag:

There are many advantages to the rectal administration of cannabis not afforded by other routes. Medicine may still be administered even if the oral route is impaired (e.g., due to vomiting, an injured jaw or throat, or gastrointestinal difficulties) or disallowed due to the oral intake restrictions that are frequently required both before and after surgery. Avoiding the gastrointestinal tract also prevents first-pass metabolism by the stomach and liver, which break down many different molecules into their constituent parts (including Δ9-tetrahydrocannabinol, otherwise known as THC), and allows the active constituents to reach the blood in much higher concentrations.

In the case of THC, the liver transforms around half of what is ingested into the significantly more psychoactive metabolite 11-Hydroxy-Δ9-tetrahydrocannabinol. While not harmful in and of itself and potentially of therapeutic benefit, this molecule causes much more intense cognitive effects than THC. Rectal administration not only avoids these effects, but also allows a much greater proportion of THC to eventually reach the blood stream. This increase in overall efficiency is also shown in the different levels of bioavailability that different administration routes afford, as seen in Fig. 1. Rectal administration also allows for medicine to exert effects over localized ailments (e.g., hemorrhoidal tissue, inflammation of the rectum, or tumours in the rectal cavity). This form of use also has a much faster uptake than oral administration (around 10 minutes, on average) and leads to more consistent blood concentrations of the active constituents. The speed and reliability of their uptake combined with their circumvention of many of the issues surrounding both ingestion and inhalation make rectal applications an excellent addition to both new and pre-existing therapeutic regimens.

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Fig. 1 – Comparative bioavailability of different administration routes
Inhalation : 10 – 25% efficiency, highly variable, depends largely on the individual’s level of experience
Oral : around 20% efficiency, highly variable, even between doses within a single individual
Rectal : around 50% – 70% efficiency, with predictable effects even between different individuals

 

Weight 5 oz
THC Content (mg)

2.5mg

CBD Content (mg)

5mg

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